Sahin Naqvi

We aim to understand how transcription factors (TFs) ensure adequate and timely gene expression in human development. To do this, we combine chemical genetic tools to quantitatively manipulate TF function, sequence-to-activity deep learning approaches, and human pluripotent stem cell-based modeling. Our goal is to shed light on the numerous disorders caused by quantitative TF disruptions and leverage these insights to improve the precision and effectiveness of cell therapies.