We aim to understand how transcription factors (TFs) ensure adequate and timely gene expression in human development. To do this, we combine chemical genetic tools to quantitatively manipulate TF function, sequence-to-activity deep learning approaches...
Kaitlin Samocha is an Assistant Professor in the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School. She is on the steering committee for the Genome Aggregation Database (gnomAD), one of the world’s largest publicly...
Genomics of human disease. We are interested in the functional consequences of the complete spectrum of genomic variation on human disease, with a particular focus on congenital birth defects, autism, neurodevelopmental disorders, and diverse...
Mutational processes in cancer and normal cells; development of computational methods for genome and epigenome analysis.
We employ computational and statistical approaches to study various types of somatic mutations that arise in cancer cells and neurons...
Benjamin Neale is an assistant professor in the Analytic and Translational Genetics Unit at Massachusetts General Hospital (MGH), assistant professor in medicine at Harvard Medical School (HMS), and an associated researcher at the Broad Institute. Neale...
Dr. Daly's lab focuses on computational approaches to understanding the genetics of disease with a strategy of integrating powerful techniques from human and mouse genetics. The lab has extensive experience in linkage and association analysis and has...
The Avillach Lab, led by Paul Avillach, M.D., Ph.D., focuses on translational bioinformatics, specifically in integrating multiple heterogeneous sources of clinical and genomic data in a meaningful way. We are passionate about combining data across...
