Regulatory Genomics

We aim to understand how transcription factors (TFs) ensure adequate and timely gene expression in human development. To do this, we combine chemical genetic tools to quantitatively manipulate TF function, sequence-to-activity deep learning approaches...

Dongwon Lee’s laboratory aims to understand how gene regulation contributes to the development and progression of human diseases, specifically focusing on kidney diseases. We use a combination of single-cell multiomics data, genetic data from disease...