Modeling/theory

We aim to understand how transcription factors (TFs) ensure adequate and timely gene expression in human development. To do this, we combine chemical genetic tools to quantitatively manipulate TF function, sequence-to-activity deep learning approaches...

The Flannick Lab develops computational approaches to use human genetics to understand or better treat human diseases, with a current focus on diabetes. We are based at Boston Children’s Hospital, Harvard Medical School, and the Broad Institute; perform...

The Huang Lab develops and applies cutting-edge statistical genetics and computational techniques to understand the genetic architecture of human complex disorders, especially autoimmune and psychiatric disorders. We are especially interested in novel...

Research:

AI holds tremendous promise in enabling scientific breakthroughs and discoveries in diverse areas. Dr. Zitnik investigates machine learning with a current focus on networked systems that require infusing structure and domain knowledge. This...

Chirag Patel is an Associate Professor of Biomedical Informatics at Harvard Medical School. Chirag Patel’s long-term research goal is to address problems in human health and disease by developing computational and bioinformatics methods to reproducibly...

Benjamin Neale is an assistant professor in the Analytic and Translational Genetics Unit at Massachusetts General Hospital (MGH), assistant professor in medicine at Harvard Medical School (HMS), and an associated researcher at the Broad Institute. Neale...

The Mirny lab has been working on genomic analysis and biophysical modeling of various molecular systems. Our efforts are focused on characterization of higher-order chromatin structure and are aimed to reveal basic physical and biological principles that...

We develop computational tools to solve statistical and algorithmic challenges in quantitative genetics.

We are based in the Division of Genetics and Center for Data Sciences at Brigham and Women's Hospital / Harvard Medical School. We are affiliated...

A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...

Dr. Daly's lab focuses on computational approaches to understanding the genetics of disease with a strategy of integrating powerful techniques from human and mouse genetics. The lab has extensive experience in linkage and association analysis and has...