Epigenetics

We aim to understand how transcription factors (TFs) ensure adequate and timely gene expression in human development. To do this, we combine chemical genetic tools to quantitatively manipulate TF function, sequence-to-activity deep learning approaches...

Our lab develops and applies computational methods in an emerging space we call “translational epigenomics”. This space encompasses efforts to advance precision oncology by deeply characterizing cancer epigenomes. By examining epigenetic changes in...

Dr. Dietlein is an Assistant Professor at Harvard Medical School, an Associate Member of the Broad Institute, Core Faculty in the Computational Health Informatics Program at Boston Children’s Hospital, and an Investigator at the Dana-Farber Cancer...

David Page’s laboratory explores fundamental differences between males and females in health and disease, both within and beyond the reproductive tract.  

The Mirny lab has been working on genomic analysis and biophysical modeling of various molecular systems. Our efforts are focused on characterization of higher-order chromatin structure and are aimed to reveal basic physical and biological principles that...

Diverse control mechanisms converge to ensure that gene transcripts are expressed and processed accurately. Dissection of these interactions has proven challenging, because most experimental approaches record downstream products fed by multiple pathways...

Our laboratory seeks to advance our understanding of gene regulation biology using single-cell methods. To do this, we develop new technologies that integrate molecular biology, microscopy, and large-scale bioinformatics. These efforts include new methods...

We develop computational and statistical methods for extracting signal from noisy genomic datasets, with a focus on cancer epigenomics. Our group members' interests range from understanding the basic epigenetic mechanisms underlying human disease, to...