We use frog egg extracts to study the molecular mechanisms underlying DNA replication and repair, and how these processes go awry in human disease. We are working on the following areas:
1. DNA cross-link repair. Our cells are constantly exposed to...
I am principal investigator of the Korsunsky lab at Brigham and Women’s Hospital. I completed my PhD with Dr. Bud Mishra at NYU’s Courant Institute of Mathematical Sciences. I started my postdoctoral training in rheumatology with Dr. Peter Gregersen at...
Our group develops and applies efficient and accurate statistical methods and computational tools to understand the genetic/genomic basis of human disease risk and progression using large-scale biobanks. We also leverage high-dimensional omics data to...
Our lab is interested in studying the mechanisms of spatio-temporal tumor evolution, progression and therapy response. Our current research focuses on scalable inference methods and modeling of single-cell genomic and in situ imaging data to study the co...
Kaitlin Samocha is an Assistant Professor in the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School. She is on the steering committee for the Genome Aggregation Database (gnomAD), one of the world’s largest publicly...
We aim to understand how transcription factors (TFs) ensure adequate and timely gene expression in human development. To do this, we combine chemical genetic tools to quantitatively manipulate TF function, sequence-to-activity deep learning approaches...
