The Huang Lab pioneers computational approaches to characterize somatic mutations across diverse sequencing technologies and leverages these innovations to understand their impact on health and disease. Somatic mutations accumulate throughout development...
The Xia lab seeks to address one of biology’s central questions: how does the human genome control the identity and function of thousands of cell types, and what goes wrong with the cells in conditions like aging and cancer? In our lab, we combine state...
We aim to understand how transcription factors (TFs) ensure adequate and timely gene expression in human development. To do this, we combine chemical genetic tools to quantitatively manipulate TF function, sequence-to-activity deep learning approaches...
Kaitlin Samocha is an Assistant Professor in the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School. She is on the steering committee for the Genome Aggregation Database (gnomAD), one of the world’s largest publicly...
Our lab is interested in studying the mechanisms of spatio-temporal tumor evolution, progression and therapy response. Our current research focuses on scalable inference methods and modeling of single-cell genomic and in situ imaging data to study the co...
Our group develops and applies efficient and accurate statistical methods and computational tools to understand the genetic/genomic basis of human disease risk and progression using large-scale biobanks. We also leverage high-dimensional omics data to...
Doga is the Principal Investigator of the Gulhan Lab at the Krantz Family Center for Cancer Research at Mass General Hospital (MGH) and an Assistant Professor of Medicine and of Biomedical Informatics (secondary) at Harvard Medical School (HMS). She...
We use frog egg extracts to study the molecular mechanisms underlying DNA replication and repair, and how these processes go awry in human disease. We are working on the following areas:
1. DNA cross-link repair. Our cells are constantly exposed to...
My lab studies the development and evolution of cancer through analysis of intratumoral genetic, transcriptional, and immunological heterogeneity. Our work lies at the intersection of computational biology, molecular biology, and medicine: Using...
I am a computational biologist working on interpreting genetic variation from large-scale datasets. As exome and genome data grow to massive scales, the methods and analytical frameworks need to scale at the same rate, and interpreting results from large...
