We aim to understand how transcription factors (TFs) ensure adequate and timely gene expression in human development. To do this, we combine chemical genetic tools to quantitatively manipulate TF function, sequence-to-activity deep learning approaches...
Our lab is interested in studying the mechanisms of spatio-temporal tumor evolution, progression and therapy response. Our current research focuses on scalable inference methods and modeling of single-cell genomic and in situ imaging data to study the co...
Our group develops and applies efficient and accurate statistical methods and computational tools to understand the genetic/genomic basis of human disease risk and progression using large-scale biobanks. We also leverage high-dimensional omics data to...
The Smillie Lab uses systems approaches to understand the mechanisms of host-microbiome interactions. Our research interests are broad, spanning mucosal immunology, microbiome evolution and ecology, and tissue biology, while relying on a combination of...
Our laboratory utilizes human genetic approaches to gain insight into blood cell production (hematopoiesis) and how this process is perturbed in disease states. We study rare genetic blood disorders and the genetics underlying variation in hematopoiesis...
We are trying to understand how circulating cells manage to leave the blood stream and home to distinct organs or tissues where they may have crucial physiologic functions or may cause disease. Despite considerable progress in this field, it is still...
Work in the Seidman laboratory (Dept of Genetics, HMS) is directed toward identifying gene defects that cause inherited heart disease and defining the pathways by which these mutations mediate disease. We begin by using human genetic techniques to...
