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Our laboratory seeks to advance our understanding of gene regulation biology using single-cell methods. To do this, we develop new technologies that integrate molecular biology, microscopy, and large-scale bioinformatics. These efforts include new methods...

The Mirny lab has been working on genomic analysis and biophysical modeling of various molecular systems. Our efforts are focused on characterization of higher-order chromatin structure and are aimed to reveal basic physical and biological principles that...

Dr. Dietlein is an Assistant Professor at Harvard Medical School, an Associate Member of the Broad Institute, Core Faculty in the Computational Health Informatics Program at Boston Children’s Hospital, and an Investigator at the Dana-Farber Cancer...

Mutational processes in cancer and normal cells; development of computational methods for genome and epigenome analysis.

We employ computational and statistical approaches to study various types of somatic mutations that arise in cancer cells and neurons...