Gad Getz directs the Cancer Genome Computational Analysis group at the Broad Institute of MIT and Harvard, where he is an institute member. Under Getz's leadership, the Cancer Genome Analysis group has established itself as a world leader in the...
Benjamin Neale is an assistant professor in the Analytic and Translational Genetics Unit at Massachusetts General Hospital (MGH), assistant professor in medicine at Harvard Medical School (HMS), and an associated researcher at the Broad Institute. Neale...
Mutational processes in cancer and normal cells; development of computational methods for genome and epigenome analysis.
We employ computational and statistical approaches to study various types of somatic mutations that arise in cancer cells and neurons...
The Rheinbay laboratory concentrates on identifying and functionally characterizing non-coding drivers in the sequences of tumor genomes through development of novel analysis strategies and collaborations with experimental investigators.
Most known...
Data generated by the rapidly advancing DNA sequencing technology provide the complete picture of population genetic variation and sequence divergence between species. We have been focused on the analysis of systematic re-sequencing datasets with the...
Rafael Irizarry received his Bachelor's in Mathematics in 1993 from the University of Puerto Rico and went on to receive a Ph.D. in Statistics in 1998 from the University of California, Berkeley. His thesis work was on Statistical Models for Music Sound...
We strive to discover genomic and infectious causes for human cancers. We then seek to apply these discoveries to understand mechanisms of cancer pathogenesis, and to improve cancer diagnosis and treatment. A particular focus is lung cancer pathogenesis...
I am a computational biologist studying the role of chromatin structure/dynamics and non-coding regions including enhancers, promoters, insulators and their role in gene regulation. The mission of my lab is the integration of omics data to explore and...
My laboratory studies chromosomal abnormalities in cancer. Examples of such alterations include aneuploidy, whole-genome duplication, and complex chromosomal rearrangements. Despite their prevalence, the origin and functional impact of these alterations...
Genetic studies for a wide variety of traits and diseases have grown exponentially over the last decade, providing fine-scale biological insights into disease mechanisms. However, these genetic studies have been vastly Eurocentric in composition. We have...
The overall goal of our work is to solve biological problems using quantitative methods from bioinformatics, statistical physics, data sciences, statistics, computer science, and mathematics. We apply these computational methods to build predictive...
