The Xia lab seeks to address one of biology’s central questions: how does the human genome control the identity and function of thousands of cell types, and what goes wrong with the cells in conditions like aging and cancer? In our lab, we combine state...
Kaitlin Samocha is an Assistant Professor in the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School. She is on the steering committee for the Genome Aggregation Database (gnomAD), one of the world’s largest publicly...
Our lab is interested in studying the mechanisms of spatio-temporal tumor evolution, progression and therapy response. Our current research focuses on scalable inference methods and modeling of single-cell genomic and in situ imaging data to study the co...
Our group develops and applies efficient and accurate statistical methods and computational tools to understand the genetic/genomic basis of human disease risk and progression using large-scale biobanks. We also leverage high-dimensional omics data to...
Doga is the Principal Investigator of the Gulhan Lab at the Krantz Family Center for Cancer Research at Mass General Hospital (MGH) and an Assistant Professor of Medicine and of Biomedical Informatics (secondary) at Harvard Medical School (HMS). She...
My lab studies the development and evolution of cancer through analysis of intratumoral genetic, transcriptional, and immunological heterogeneity. Our work lies at the intersection of computational biology, molecular biology, and medicine: Using...
The Rheinbay laboratory concentrates on identifying and functionally characterizing non-coding drivers in the sequences of tumor genomes through development of novel analysis strategies and collaborations with experimental investigators.
Most known genomic...
Genetic studies for a wide variety of traits and diseases have grown exponentially over the last decade, providing fine-scale biological insights into disease mechanisms. However, these genetic studies have been vastly Eurocentric in composition. We have...
