Genome analysis

My laboratory studies chromosomal abnormalities in cancer. Examples of such alterations include aneuploidy, whole-genome duplication, and complex chromosomal rearrangements. Despite their prevalence, the origin and functional impact of these alterations...

Our lab is interested in identifying mechanisms that regulate the normal development and function of the human cerebral cortex. The cortex is the largest structure in the brain, essential for the intellectual functions that we humans pride ourselves on...

We are trying to understand how circulating cells manage to leave the blood stream and home to distinct organs or tissues where they may have crucial physiologic functions or may cause disease. Despite considerable progress in this field, it is still...

The Van Galen Laboratory studies molecular mechanisms that sustain the human blood system throughout life. Specific projects focus hematopoietic stem cell biology, diminished immune cell function with age and changes that underly the development of blood...

To drive precision cancer medicine through clinical computational oncology:
Creating the engine to clinically interpret a patient's cancer genome
Discovering response and resistance mechanisms to cancer therapies through patient-centered molecular profiling...

Genomics of human disease. We are interested in the functional consequences of the complete spectrum of genomic variation on human disease, with a particular focus on congenital birth defects, autism, neurodevelopmental disorders, and diverse...

Data generated by the rapidly advancing DNA sequencing technology provide the complete picture of population genetic variation and sequence divergence between species. We have been focused on the analysis of systematic re-sequencing datasets with the...

Work in the Seidman laboratory (Dept of Genetics, HMS) is directed toward identifying gene defects that cause inherited heart disease and defining the pathways by which these mutations mediate disease. We begin by using human genetic techniques to...

The lab is focused on developing and applying computational and statistical methods that integrate large-scale human genetics, single cell and functional genomics and systems biology data to uncover the causal genes and regulatory mechanisms of complex...

Dr. Pardis Sabeti is an Associate Professor at the Center for Systems Biology and Department of Organismic and Evolutionary Biology at Harvard University and the Department of Immunology and Infectious Disease at the Harvard School of Public Health, and...