Experimental

Our lab's projects lie at the intersection of genetics, neurobiology, and bioinformatics, which we apply to understand (and treat) rare pediatric neurologic diseases. 

Autism genetics and neurobiology: We apply whole exome and whole genome sequencing to...

Our lab is interested in identifying mechanisms that regulate the normal development and function of the human cerebral cortex. The cortex is the largest structure in the brain, essential for the intellectual functions that we humans pride ourselves on...

We are trying to understand how circulating cells manage to leave the blood stream and home to distinct organs or tissues where they may have crucial physiologic functions or may cause disease. Despite considerable progress in this field, it is still...

The Van Galen Laboratory studies molecular mechanisms that sustain the human blood system throughout life. Specific projects focus hematopoietic stem cell biology, diminished immune cell function with age and changes that underly the development of blood...

My research program focuses on the integration of "omic" approaches for the identification of new protein targets and small-molecule modulators of malignancy with an eye toward clinical translation. Cancer discovery efforts in my laboratory have focused...

Work in the Seidman laboratory (Dept of Genetics, HMS) is directed toward identifying gene defects that cause inherited heart disease and defining the pathways by which these mutations mediate disease. We begin by using human genetic techniques to...

The Seidman laboratory uses genetic techniques to study the molecular basis of inherited human disorders. A central project in the laboratory has been to understand the genetic basis of inherited cardiovascular diseases. Genetic work on Familial...

Several long-term research projects in human genetics are ongoing in the Morton laboratory. An overall theme is to apply evolving techniques in molecular cytogenetics to address problems in human cytogenetics; our interests include chromosomal...

Our team seeks to understand how molecular & cellular signaling dynamics are spatially controlled in tissue, and how they can be therapeutically manipulated to treat disease.   

We focus on inflammation and cancer, and combine an interdisciplinary...

We strive to discover genomic and infectious causes for human cancers. We then seek to apply these discoveries to understand mechanisms of cancer pathogenesis, and to improve cancer diagnosis and treatment. A particular focus is lung cancer pathogenesis...