Complex disease

Our group develops and applies efficient and accurate statistical methods and computational tools to understand the genetic/genomic basis of human disease risk and progression using large-scale biobanks. We also leverage high-dimensional omics data to...

Dongwon Lee’s laboratory aims to understand how gene regulation contributes to the development and progression of human diseases, specifically focusing on kidney diseases. We use a combination of single-cell multiomics data, genetic data from disease...

The Flannick Lab develops computational approaches to use human genetics to understand or better treat human diseases, with a current focus on diabetes. We are based at Boston Children’s Hospital, Harvard Medical School, and the Broad Institute; perform...

Genetic studies for a wide variety of traits and diseases have grown exponentially over the last decade, providing fine-scale biological insights into disease mechanisms. However, these genetic studies have been vastly Eurocentric in composition. We have...

David Page’s laboratory explores fundamental differences between males and females in health and disease, both within and beyond the reproductive tract.  

The Huang Lab develops and applies cutting-edge statistical genetics and computational techniques to understand the genetic architecture of human complex disorders, especially autoimmune and psychiatric disorders. We are especially interested in novel...

Our laboratory utilizes human genetic approaches to gain insight into blood cell production (hematopoiesis) and how this process is perturbed in disease states. We study rare genetic blood disorders and the genetics underlying variation in hematopoiesis...

Research:

AI holds tremendous promise in enabling scientific breakthroughs and discoveries in diverse areas. Dr. Zitnik investigates machine learning with a current focus on networked systems that require infusing structure and domain knowledge. This...

Kun-Hsing "Kun" Yu, MD, PhD is an Assistant Professor in the Department of Biomedical Informatics at Harvard Medical School. His lab integrates cancer patients' multi-omics (genomics, epigenomics, transcriptomics, and proteomics) profiles with...

Our lab is interested in identifying mechanisms that regulate the normal development and function of the human cerebral cortex. The cortex is the largest structure in the brain, essential for the intellectual functions that we humans pride ourselves on...