Our lab develops and applies computational methods in an emerging space we call “translational epigenomics”. This space encompasses efforts to advance precision oncology by deeply characterizing cancer epigenomes. By examining epigenetic changes in...
The Lotter Lab performs interdisciplinary research with two core aims: 1) developing more robust computer vision algorithms using insights from human vision, and 2) optimizing these algorithms for medical imaging to deliver real-world impact. We aim to...
My laboratory studies chromosomal abnormalities in cancer. Examples of such alterations include aneuploidy, whole-genome duplication, and complex chromosomal rearrangements. Despite their prevalence, the origin and functional impact of these alterations...
The overall goal of our work is to solve biological problems using quantitative methods from bioinformatics, statistical physics, data sciences, statistics, computer science, and mathematics. We apply these computational methods to build predictive...
We strive to discover genomic and infectious causes for human cancers. We then seek to apply these discoveries to understand mechanisms of cancer pathogenesis, and to improve cancer diagnosis and treatment. A particular focus is lung cancer pathogenesis...
Todd Golub is a founding core member of the Broad Institute and serves as the institute director.
Golub is a world leader in understanding the basis of cancer, by creating and applying tools of genomics. He has made fundamental discoveries in the...
The Beroukhim laboratory focuses on understanding the somatic genetics of cancer, primarily in identifying alterations in chromosomal structure (including copy-number gains and losses and loss of heterozygosity) that contribute to tumor growth, and...
