The Smillie Lab uses systems approaches to understand the mechanisms of host-microbiome interactions. Our research interests are broad, spanning mucosal immunology, microbiome evolution and ecology, and tissue biology, while relying on a combination of...
Our laboratory utilizes human genetic approaches to gain insight into blood cell production (hematopoiesis) and how this process is perturbed in disease states. We study rare genetic blood disorders and the genetics underlying variation in hematopoiesis...
Immune-mediated diseases such as lupus or rheumatoid arthritis are not caused by an isolated insult resulting in a single dysfunctional gene or pathway, but rather a systemic dysregulation of multiple genes and pathways. Our group uses methods in...
One million human genomes, will it make a difference? The large and growing volume of genome information, from all forms of life, presents unprecedented opportunities for computational biologists. The challenge for our scientific generation is to turn an...
My lab studies the interplay between the gut microbiome and the immune system and how their “miscues” can lead to autoimmune diseases, particularly type 1 diabetes. As a 2013 BBS grad, I understand what it takes to have a successful Ph.D. experience.
The...
The Hacohen lab consists of immunologists, geneticists, biochemists, technologists, physicians and computational biologists working together to develop new and unbiased technologies and strategies to understand basic immune processes and immune-mediated...
A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage...
Dr. Daly's lab focuses on computational approaches to understanding the genetics of disease with a strategy of integrating powerful techniques from human and mouse genetics. The lab has extensive experience in linkage and association analysis and has...
