Our lab is interested in studying the mechanisms of spatio-temporal tumor evolution, progression and therapy response. Our current research focuses on scalable inference methods and modeling of single-cell genomic and in situ imaging data to study the co...
Dr. Dietlein is an Assistant Professor at Harvard Medical School, an Associate Member of the Broad Institute, Core Faculty in the Computational Health Informatics Program at Boston Children’s Hospital, and an Investigator at the Dana-Farber Cancer...
Genetic studies for a wide variety of traits and diseases have grown exponentially over the last decade, providing fine-scale biological insights into disease mechanisms. However, these genetic studies have been vastly Eurocentric in composition. We have...
The Smillie Lab uses systems approaches to understand the mechanisms of host-microbiome interactions. Our research interests are broad, spanning mucosal immunology, microbiome evolution and ecology, and tissue biology, while relying on a combination of...
My laboratory studies chromosomal abnormalities in cancer. Examples of such alterations include aneuploidy, whole-genome duplication, and complex chromosomal rearrangements. Despite their prevalence, the origin and functional impact of these alterations...
Dr. Pardis Sabeti is an Associate Professor at the Center for Systems Biology and Department of Organismic and Evolutionary Biology at Harvard University and the Department of Immunology and Infectious Disease at the Harvard School of Public Health, and...
We develop computational tools to solve statistical and algorithmic challenges in quantitative genetics.
We are based in the Division of Genetics and Center for Data Sciences at Brigham and Women's Hospital / Harvard Medical School. We are affiliated...
The Beroukhim laboratory focuses on understanding the somatic genetics of cancer, primarily in identifying alterations in chromosomal structure (including copy-number gains and losses and loss of heterozygosity) that contribute to tumor growth, and...
