Our lab is interested in studying the mechanisms of spatio-temporal tumor evolution, progression and therapy response. Our current research focuses on scalable inference methods and modeling of single-cell genomic and in situ imaging data to study the co...
Our lab develops and applies computational methods in an emerging space we call “translational epigenomics”. This space encompasses efforts to advance precision oncology by deeply characterizing cancer epigenomes. By examining epigenetic changes in...
The Rheinbay laboratory concentrates on identifying and functionally characterizing non-coding drivers in the sequences of tumor genomes through development of novel analysis strategies and collaborations with experimental investigators.
Most known...
The Lotter Lab performs interdisciplinary research with two core aims: 1) developing more robust computer vision algorithms using insights from human vision, and 2) optimizing these algorithms for medical imaging to deliver real-world impact. We aim to...
Dr. Dietlein is an Assistant Professor at Harvard Medical School, an Associate Member of the Broad Institute, Core Faculty in the Computational Health Informatics Program at Boston Children’s Hospital, and an Investigator at the Dana-Farber Cancer...
My laboratory studies chromosomal abnormalities in cancer. Examples of such alterations include aneuploidy, whole-genome duplication, and complex chromosomal rearrangements. Despite their prevalence, the origin and functional impact of these alterations...
We are trying to understand how circulating cells manage to leave the blood stream and home to distinct organs or tissues where they may have crucial physiologic functions or may cause disease. Despite considerable progress in this field, it is still...
