BIG Faculty

Although numerous eukaryotic genomes have been sequenced, much still remains to be understood about how the genes in those genomes are regulated. The interactions between transcription factors (TFs) and their DNA binding sites are an integral part of the...

Our laboratory seeks to advance our understanding of gene regulation biology using single-cell methods. To do this, we develop new technologies that integrate molecular biology, microscopy, and large-scale bioinformatics. These efforts include new methods...

The Beroukhim laboratory focuses on understanding the somatic genetics of cancer, primarily in identifying alterations in chromosomal structure (including copy-number gains and losses and loss of heterozygosity) that contribute to tumor growth, and...

Bonnie Berger is a Professor of Applied Mathematics and Computer Science at MIT, and head of the Computation and Biology group at MIT's Computer Science and AI Lab. After beginning her career working in algorithms at MIT, she was one of the pioneer...

Our research crosses a broad spectrum of areas, centered around microbial evolutionary genomics and antibiotic resistance. Our projects are curiosity-driven and range from fundamental evolutionary questions, to genetic arms races, to algorithmic and...

The Avillach Lab, led by Paul Avillach, M.D., Ph.D.,  focuses on translational bioinformatics, specifically in integrating multiple heterogeneous sources of clinical and genomic data in a meaningful way. We are passionate about combining data across...

We develop computational and statistical methods for extracting signal from noisy genomic datasets, with a focus on cancer epigenomics. Our group members' interests range from understanding the basic epigenetic mechanisms underlying human disease, to...