# George Mcdonald Church Robert Winthrop Professor of Genetics ![church_george.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__480x600/public/bigphd/files/church_george_0.jpg?itok=YKAnOHHt) location\_on Harvard Medical School Genetics, NRB, Rm. 238D 77 Avenue Louis Pasteur Boston, MA 02115 smartphone [617-432-7562](tel:617-432-7562) email laptop\_windows [Lab Website](https://arep.med.harvard.edu/) laptop\_windows [Publications](https://arep.med.harvard.edu/gmc_pub.html) Our research focuses on new technologies for genomic & proteomic measurement, synthesis and modeling of biomedical & ecological systems -- in particular, personal genomics and biofuels. We have developed next-generation sequencing methods to analyze the output of combinatorial selections as well as comprehensive gene-environment-trait data for affordable personalized medicine. We reprogram human skin-derived pluripotent skin cells to connect cis-regulatory motif variants in populations to allele-specific and cell-type-specific RNA measures and further to causal effects on cell and larger-scale morphologies. We are developing tools for connecting functional microbiomics with (VDJ-ome) immune responses. - ## AIM or BIG Faculty [BIG Faculty](/aim-and-big-faculty/big-faculty) - ## Biological/Medical Focus [Aging/neurodegeneration](/biologicalmedical-focus/agingneurodegeneration) [Development](/biologicalmedical-focus/development) - ## Faculty research type [Hybrid of computational and experimental](/faculty-research-type/hybrid-computational-and-experimental) - ## Methodological Focus [ML/AI](/methodological-focus/mlai) [Transcriptomics](/methodological-focus/transcriptomics) - ## People [BIG Program Faculty](/people/BIGfaculty) - ## Primary affiliation [HMS (Genetics/SysBio)](/primary-affiliation/hms) - ## Research Area [Genome sequencing technologies; synthetic biology and cell/tissue engineering](/research-area/genome-sequencing-technologies-synthetic-biology-and-celltissue-engineering)