# Faculty BIG currently has 83 faculty members. Students may choose from BIG faculty labs or anyone in HILS if appropriate. See HILS faculty directory [**here**](https://instructors.my.harvard.edu/)**.** [### Martin Aryee ](/people/martin-aryee) Associate Professor of Pathology We develop computational and statistical methods for extracting signal from noisy genomic datasets, with a focus on cancer epigenomics. Our group members' interests range from understanding the basic epigenetic mechanisms underlying human disease, to... ![aryee_martin.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/aryee_martin.jpg?itok=zj9s-6y9) [### Paul Avillach ](/people/paul-avillach) [Paul\_Avillach@hms.harvard.edu](mailto:Paul_Avillach@hms.harvard.edu)Assistant Professor of Biomedical Informatics The Avillach Lab, led by Paul Avillach, M.D., Ph.D., focuses on translational bioinformatics, specifically in integrating multiple heterogeneous sources of clinical and genomic data in a meaningful way. We are passionate about combining data across... ![paul_avillach_0.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/paul_avillach_0.jpg?itok=T1o1dF5N) [### Sylvan Baca ](/people/sylvan-baca) Assistant Professor of Medicine Our lab develops and applies computational methods in an emerging space we call “translational epigenomics”. This space encompasses efforts to advance precision oncology by deeply characterizing cancer epigenomes. By examining epigenetic changes in... ![baca_sylvan.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/baca_sylvan.jpg?itok=a6tYBTkq) [### Michael Baym ](/people/michael-baym) Assistant Professor of Biomedical Informatics Our research crosses a broad spectrum of areas, centered around microbial evolutionary genomics and antibiotic resistance. Our projects are curiosity-driven and range from fundamental evolutionary questions, to genetic arms races, to algorithmic and... ![baym_michael.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/baym_michael.jpg?itok=ogIRXewe) [### Bonnie Berger ](/people/bonnie-berger) Member of the Harvard-MIT Health Sciences and Technology Faculty Bonnie Berger is a Professor of Applied Mathematics and Computer Science at MIT, and head of the Computation and Biology group at MIT's Computer Science and AI Lab. After beginning her career working in algorithms at MIT, she was one of the pioneer... ![berger_bonnie.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/berger_bonnie.jpg?itok=eZis0kKD) [### Rameen Beroukhim ](/people/rameen-beroukhim) [rameen\_beroukhim@dfci.harvard.edu](mailto:rameen_beroukhim@dfci.harvard.edu)Associate Professor of Medicine The Beroukhim laboratory focuses on understanding the somatic genetics of cancer, primarily in identifying alterations in chromosomal structure (including copy-number gains and losses and loss of heterozygosity) that contribute to tumor growth, and... ![beroukhim_rameen.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/beroukhim_rameen_1.jpg?itok=ODp3k7Jb) [### Jason Daniel Buenrostro ](/people/jason-daniel-buenrostro) [jason\_buenrostro@harvard.edu](mailto:jason_buenrostro@harvard.edu)Assistant Professor of Stem Cell and Regenerative Biology Our laboratory seeks to advance our understanding of gene regulation biology using single-cell methods. To do this, we develop new technologies that integrate molecular biology, microscopy, and large-scale bioinformatics. These efforts include new methods... ![buenrostro_jason.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/buenrostro_jason.jpg?itok=0DpyS90e) [### Martha Leonia Bulyk ](/people/martha-leonia-bulyk) Professor of Medicine Although numerous eukaryotic genomes have been sequenced, much still remains to be understood about how the genes in those genomes are regulated. The interactions between transcription factors (TFs) and their DNA binding sites are an integral part of the... ![bulyk_martha.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/bulyk_martha_2.jpg?itok=H36cYfPw) [### Tianxi Cai ](/people/tianxi-cai) John Rock Professor of Population and Translational Data Sciences Tianxi Cai is a major player in developing analytical tools for mining EHR data and predictive modeling with biomedical data. She provides statistical leadership on several large-scale projects, including the NIH-funded Undiagnosed Diseases Network at... ![cai_tianxi.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/cai_tianxi.jpg?itok=bH6wSYoK) [### Christopher Cassa ](/people/christopher-cassa) Assistant Professor of Medicine Our research group studies the statistical genetics of Mendelian disorders. We focus on two major application areas: methods to assess the pathogenicity of genomic variants and the clinical application of predictive algorithms in genomics. These... ![cassa_christopher.jpeg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/cassa_christopher.jpeg?itok=QvkyrKty) [### Kaifu Chen ](/people/kaifu-chen) Associate Professor of Pediatrics We are a bioinformatics lab developing computation technology to model how cell identity is established during differentiation. We develop bioinformatics methods to understand genetic, epigenetic, and molecular signaling mechanisms in cell identity... ![chen_kaifu.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/chen_kaifu.jpg?itok=0-wmxgKI) [### George Mcdonald Church ](/people/george-mcdonald-church) Robert Winthrop Professor of Genetics Our research focuses on new technologies for genomic & proteomic measurement, synthesis and modeling of biomedical & ecological systems -- in particular, personal genomics and biofuels. We have developed next-generation sequencing methods to analyze the... ![church_george.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/church_george_0.jpg?itok=GLRP30Vr) [### Stirling Churchman ](/people/stirling-churchman) Associate Professor of Genetics Diverse control mechanisms converge to ensure that gene transcripts are expressed and processed accurately. Dissection of these interactions has proven challenging, because most experimental approaches record downstream products fed by multiple pathways –... ![churchman_stirling.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/churchman_stirling.jpg?itok=8vzYvAG7) [### Mark Joseph Daly ](/people/mark-joseph-daly) Associate Professor of Medicine Dr. Daly's lab focuses on computational approaches to understanding the genetics of disease with a strategy of integrating powerful techniques from human and mouse genetics. The lab has extensive experience in linkage and association analysis and has... ![daly_mark.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/daly_mark.jpg?itok=hgtMttE2) [### Felix Dietlein ](/people/felix-dietlein) Assistant Professor of Pediatrics Dr. Dietlein is an Assistant Professor at Harvard Medical School, an Associate Member of the Broad Institute, Core Faculty in the Computational Health Informatics Program at Boston Children’s Hospital, and an Investigator at the Dana-Farber Cancer... ![dietlein_felix.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/dietlein_felix.jpg?itok=atQ9rb_8) [### Stephen J. Elledge ](/people/stephen-j-elledge) Gregor Mendel Professor of Genetics and of Medicine A major area of our interest is how eukaryotic cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage, they induce the transcription of genes involved in cell cycle arrest and repair of the damage... ![elledge_stephen_1.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/elledge_stephen_1.jpg?itok=nL5D75c3) [### Maha Farhat ](/people/maha-farhat) BIG Associate Director Associate Professor of Biomedical Informatics The Farhat lab is a translational lab that combines genomics and informatics to understand and better control drug resistant tuberculosis and other infections. We are particularly interested in bacterial genome wide association, prediction of phenotype... ![Maha Farhat](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/2025-06/Maha_Farhat.jpg?h=ae6421f8&itok=jYYZTcCV) [### Jason Flannick ](/people/jason-flannick) Assistant Professor of Pediatrics The Flannick Lab develops computational approaches to use human genetics to understand or better treat human diseases, with a current focus on diabetes. We are based at Boston Children’s Hospital, Harvard Medical School, and the Broad Institute; perform... ![flannick_jason.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/flannick_jason_4.jpg?itok=1YIPhWRk) [### Nils Gehlenborg ](/people/nils-gehlenborg) Associate Professor of Biomedical Informatics Nils Gehlenborg received his PhD from the University of Cambridge and was a predoctoral fellow at the European Bioinformatics Institute (EMBL-EBI). The goal of Gehlenborg's research is to improve human health by developing computational techniques and... ![Nils Gehlenborg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/2026-03/nils-gehlenborg.png?itok=E4epkPwg) [### Gad Getz ](/people/gad-getz) Professor of Pathology Gad Getz directs the Cancer Genome Computational Analysis group at the Broad Institute of MIT and Harvard, where he is an institute member. Under Getz's leadership, the Cancer Genome Analysis group has established itself as a world leader in the... ![getz_gad.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/getz_gad.jpg?itok=-4SNVd5W) [### Todd R. Golub ](/people/todd-r-golub) Professor of Pediatrics Todd Golub is a founding core member of the Broad Institute and serves as the institute director. Golub is a world leader in understanding the basis of cancer, by creating and applying tools of genomics. He has made fundamental discoveries in the... ![golub_todd.png](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/golub_todd.png?itok=N6z8a82k) [### Robert C. Green ](/people/robert-c-green) Professor of Medicine Robert C. Green, MD, MPH is a medical geneticist and physician-scientist who directs the G2P Research Program in translational genomics and health outcomes in the Division of Genetics at Brigham and Women's Hospital and Harvard Medical School. Dr. Green... ![green_robert.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/green_robert.jpg?itok=wl0VO__d) [### Doga Gulhan ](/people/doga-gulhan) Assistant Professor Doga is the Principal Investigator of Gulhan Lab at Mass General Hospital (MGH) Cancer Center and an Assitant Professor of Medicine and Biomedical Informatics (Secondary) at Harvard Medical School (HMS). She received her Bachelor of Science degree from... ![doga_gulhan.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/doga_gulhan_0.jpg?itok=rrrPinC9) [### James Francis Gusella ](/people/james-francis-gusella) Bullard Professor of Neurogenetics in the Department of Genetics My laboratory is focused on understanding nervous system disease using molecular genetic strategies, beginning with human patients and proceeding through in vitro and modeling studies, with the ultimate goal of improving diagnosis, management and... ![gusella_james.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/gusella_james.jpg?itok=BNsxcKYs) [### Alexander Gusev ](/people/alexander-gusev) [alexander\_gusev@dfci.harvard.edu](mailto:alexander_gusev@dfci.harvard.edu)Associate Professor of Medicine We are quantitative geneticists working on methods to understand complex disease. Our research focuses on deciphering biological mechanisms and trait biology from genome-wide association studies; germline influences of cancer and response to therapy; and... ![gusev_alexander.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/gusev_alexander.jpg?itok=fuiVsaX0) [### Steven P. Gygi ](/people/steven-p-gygi) [steven\_gygi@hms.harvard.edu](mailto:steven_gygi@hms.harvard.edu)Professor of Cell Biology Technology drives biological research. A new technology can instantly provide answers that were difficult or impossible to address using current approaches. The emerging field of proteomics provides researchers an alternative/complementary strategy to the... ![gygi_steven.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/gygi_steven.jpg?itok=r_MYZrur) [### Nir Hacohen ](/people/nir-hacohen) Professor of Medicine The Hacohen lab consists of immunologists, geneticists, biochemists, technologists, physicians and computational biologists working together to develop new and unbiased technologies and strategies to understand basic immune processes and immune-mediated... ![hacohen_nir_1.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/hacohen_nir_1.jpg?itok=ZxVVwTOF) [### Kevin M. Haigis ](/people/kevin-m-haigis) [kevin\_haigis@dfci.harvard.edu](mailto:kevin_haigis@dfci.harvard.edu)Professor of Medicine Our laboratory studies diseases of the gastrointestinal tract, with emphasis on colorectal cancer (CRC) and inflammatory bowel disease (IBD). We use both conventional and systems biology approaches to integrate studies of genetically engineered mouse... ![haigis_kevin.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/haigis_kevin.jpg?itok=ejbZp_xC) [### Joel Naom Hirschhorn ](/people/joel-naom-hirschhorn) Concordia Professor of Pediatrics There are clear resemblances between parents and children for height, weight, and many other traits and diseases; these familial resemblances are influenced strongly by inherited genetic factors. Most common diseases (such as diabetes, obesity, or asthma)... ![hirschhorn_joel.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/hirschhorn_joel.jpg?itok=qto5AtVO) [### Hailiang Huang ](/people/hailiang-huang) Assistant Professor The Huang Lab develops and applies cutting-edge statistical genetics and computational techniques to understand the genetic architecture of human complex disorders, especially autoimmune and psychiatric disorders. We are especially interested in novel... ![huang_hailiang.jpg](/sites/g/files/omnuum6836/files/styles/hwp_4_5__690x865/public/bigphd/files/huang_hailiang.jpg?itok=1hKnuB7t) - Previous page chevron\_left - [1](?page=0 "Current page") - [2](?page=1 "Go to page 2") - [3](?page=2 "Go to page 3") - [ Next page chevron\_right ](?page=1 "Go to next page") ## Search by faculty track ### AIM or BIG Faculty [AIM Faculty (9)](/aim-and-big-faculty/aim-faculty) [BIG Faculty (82)](/aim-and-big-faculty/big-faculty) ## Search by category ### AIM or BIG Faculty [AIM Faculty](/aim-and-big-faculty/aim-faculty) [BIG Faculty](/aim-and-big-faculty/big-faculty) ### Biological/Medical Focus [Aging/neurodegeneration ](/biologicalmedical-focus/agingneurodegeneration) [Cancer biology ](/biologicalmedical-focus/cancer-biology) [Cardiovascular disease](/biologicalmedical-focus/cardiovascular-disease) [Chemical biology and/or drug development ](/biologicalmedical-focus/chemical-biology-andor-drug-development) [Complex disease ](/biologicalmedical-focus/complex-disease) [Development ](/biologicalmedical-focus/development) [Diabetes or other endocrine disorders ](/biologicalmedical-focus/diabetes-or-other-endocrine-disorders) [Evolution of cells or populations ](/biologicalmedical-focus/evolution-cells-or-populations) [Evolutionary, population and statistical genetics ](/biologicalmedical-focus/evolutionary-population-and-statistical-genetics) [Gene regulation ](/biologicalmedical-focus/gene-regulation) [Genetics of human disease ](/biologicalmedical-focus/genetics-human-disease) [Immunology and aging ](/biologicalmedical-focus/immunology-and-aging) [Immunology including autoimmune ](/biologicalmedical-focus/immunology-including-autoimmune) [Infectious disease/pathogens ](/biologicalmedical-focus/infectious-diseasepathogens) [Mendelian disease ](/biologicalmedical-focus/mendelian-disease) [Neurodevelopment ](/biologicalmedical-focus/neurodevelopment) [New measurement technologies ](/biologicalmedical-focus/new-measurement-technologies) [Transposon ](/biologicalmedical-focus/transposon) ### Faculty research type [Computational ](/faculty-research-type/computational) [Experimental ](/faculty-research-type/experimental) [Hybrid of computational and experimental ](/faculty-research-type/hybrid-computational-and-experimental) ### Methodological Focus [Epigenetics ](/methodological-focus/epigenetics) [Genome analysis](/methodological-focus/genome-analysis) [Imaging analysis](/methodological-focus/imaging-analysis) [Integration of clinical and genomic data](/methodological-focus/integration-clinical-and-genomic-data) [ML/AI ](/methodological-focus/mlai) [Metabolomics ](/methodological-focus/metabolomics) [Microbiome and/or metagenomics](/methodological-focus/microbiome-andor-metagenomics) [Modeling/theory](/methodological-focus/modelingtheory) [Proteomics](/methodological-focus/proteomics) [Regulatory Genomics](/methodological-focus/regulatory-genomics) [Single cell profiling ](/methodological-focus/single-cell-profiling) [Statistical methods](/methodological-focus/statistical-methods) [Synthetic biology](/methodological-focus/synthetic-biology) [Transcriptomics](/methodological-focus/transcriptomics) ### Primary affiliation [BCH](/primary-affiliation/bch) [BWH ](/primary-affiliation/bwh) [DFCI ](/primary-affiliation/dfci) [HMS (DBMI)](/primary-affiliation/dmbi) [HMS (DBMI)/DFCI ](/primary-affiliation/dfcidbmi) [HMS (DBMI)/HSPH](/primary-affiliation/dbmihsph) [HMS (Genetics/SysBio)](/primary-affiliation/hms) [HSPH ](/primary-affiliation/hsph) [Joslin](/primary-affiliation/joslin) [MGH](/primary-affiliation/mgh) [MIT ](/primary-affiliation/mit) [Main campus](/primary-affiliation/harvard)